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Thereafter, his film career decreased and he ventured into television, making his breakthrough as Sam Seaborn on the NBC political drama The West Wing (1999–2003), for which he received a Primetime Emmy Award nomination and two Golden Globe Award nominations.In addition to his 2001 Emmy nomination for The West Wing, He is of German, English, Irish, Scottish, and Welsh ancestry. , Lowe found out that one of his ancestors, Christopher East, was a Hessian soldier.
As an American POW, his ancestor was given a choice, and took the option to stay in the United States.After leaving the show, Lowe was the star and executive producer of a failed NBC drama, The Lyon's Den (2003). Although Lowe had expressed unhappiness about his decreased role on that show at the time of his departure, he has now repeatedly said that any animosity between them is over and that he was pleased to be working once more with Sorkin, whose talents as a writer Lowe highly regards. Derek Shepherd of Grey's Anatomy, which eventually went to Patrick Dempsey.Despite his two cancelled TV series and flops like View From the Top and the made-for-TV movie Perfect Strangers during his post–West Wing run, Lowe found success in the TV miniseries genre.As Steve Rogers struggles to embrace his role in the modern world, he teams up with a fellow Avenger and S. Hank Pym, plan and pull off a heist that will save the world. D agent, Black Widow, to battle a new threat from history: an assassin known as the Winter Soldier.